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Possible Answers:
IRENE.
Last seen on: USA Today Crossword – Oct 24 2019
Random information on the term “IRENE”:
Irene of Athens[a] (c. 752 – 9 August 803 AD), also known as Irene Sarantapechaina,[b] was Byzantine empress consort by marriage to Leo IV from 775 to 780, regent during the minority of her son Constantine VI from 780 until 790, co-regent from 792 until 797, and finally sole ruler and first empress regnant of the Byzantine Empire from 797 to 802. A member of the politically prominent Sarantapechos family, she was selected as Leo IV’s bride for unknown reasons in 768. Even though her husband was an iconoclast, she harbored iconophile sympathies. During her rule as regent, she called the Second Council of Nicaea in 787, which condemned iconoclasm as heretical and brought an end to the first iconoclast period (730–787).
As Irene’s son Constantine reached maturity, he began to move out from under the influence of his mother. In the early 790s, several attempted revolts tried to proclaim him as sole ruler. In 797, Irene gouged out her son’s eyes, maiming him so severely that he died a few days later. With her son dead, Irene proclaimed herself sole ruler. Irene’s alleged unprecedented status as a female ruler of the Roman Empire (there had been women ruling the empire in their own right before, notably Pulcheria) led Pope Leo III to proclaim Charlemagne emperor of the Holy Roman Empire on Christmas Day of 800 under the pretext that a woman could not rule and so the throne of the Roman Empire was actually vacant. A revolt in 802 overthrew Irene and exiled her to the island of Lesbos, supplanting her on the throne with Nikephoros I. Irene died in exile less than a year later.