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Possible Answers: COMP.
Last seen on: USA Today Crossword – July 23 2018 Monday Crossword Answers
Random information on the term “COMP”:
3FBY
1311
12845
ENSG00000105664
ENSMUSG00000031849
P49747
Q9R0G6
NM_000095
NM_016685
NP_000086
NP_057894
Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.[5][6][7]
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.[8] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).[7]
COMP is a marker of cartilage turnover.[9] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.[10]