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Last seen on: NY Times Crossword 17 May 19, Friday
Random information on the term “#1, e.g.”:
William Henry Seward (May 16, 1801 – October 10, 1872) was United States Secretary of State from 1861 to 1869, and earlier served as governor of New York and United States Senator. A determined opponent of the spread of slavery in the years leading up to the American Civil War, he was a prominent figure in the Republican Party in its formative years, and was praised for his work on behalf of the Union as Secretary of State during the Civil War.
Seward was born in 1801 in the village of Florida, in Orange County, New York State, where his father was a farmer and owned slaves. He was educated as a lawyer and moved to the Central New York town of Auburn. Seward was elected to the New York State Senate in 1830 as an Anti-Mason. Four years later, he became the gubernatorial nominee of the Whig Party. Though he was not successful in that race, Seward was elected governor in 1838 and won a second two-year term in 1840. During this period, he signed several laws that advanced the rights of and opportunities for black residents, as well as guaranteeing fugitive slaves jury trials in the state. The legislation protected abolitionists, and he used his position to intervene in cases of freed black people who were enslaved in the South.
Random information on the term “HIT”:
Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant. HIT predisposes to thrombosis (the abnormal formation of blood clots inside a blood vessel) because platelets release microparticles that activate thrombin, thereby leading to thrombosis. When thrombosis is identified the condition is called heparin-induced thrombocytopenia and thrombosis (HITT). HIT is caused by the formation of abnormal antibodies that activate platelets. If someone receiving heparin develops new or worsening thrombosis, or if the platelet count falls, HIT can be confirmed with specific blood tests.
The treatment of HIT requires stopping heparin treatment, and both protection from thrombosis and choice of an agent that will not reduce the platelet count any further. Several alternatives are available for this purpose and mainly used are danaparoid, fondaparinux, argatroban and bivalirudin.