‘___ of Pi’ (Yann Martel novel)

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Possible Answers:

LIFE.

Last seen on: USA Today Crossword – Apr 30 2019

Random information on the term “LIFE”:

Non-cellular life, or acellular life is life that exists without a cellular structure for at least part of its life cycle. Historically, most (descriptive) definitions of life postulated that a living organism must be composed of one or more cells, but this is no longer considered necessary, and modern criteria allow for forms of life based on other structural arrangements.

The primary candidates for non-cellular life are viruses. A minority of biologists consider viruses to be living organisms, but most do not. Their primary objection is that no known viruses are capable of autonomous reproduction: they must rely on cells to copy them. However, the recent discovery of giant viruses that possess genes for part of the required translation machinery has raised the prospect that they may have had extinct ancestors that could evolve and replicate independently. Most biologists agree that such an ancestor would be a bona fide non-cellular lifeform, but its existence and characteristics are still uncertain.

LIFE on Wikipedia