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Possible Answers:
HASSLE.
Last seen on: Wall Street Journal Crossword – September 10 2020 – Getting By
Random information on the term “HASSLE”:
In bioinformatics, BLAST (basic local alignment search tool) is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences. A BLAST search enables a researcher to compare a subject protein or nucleotide sequence (called a query) with a library or database of sequences, and identify library sequences that resemble the query sequence above a certain threshold.
Different types of BLASTs are available according to the query sequences and the target databases. For example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene; BLAST will identify sequences in the human genome that resemble the mouse gene based on similarity of sequence.
BLAST, which The New York Times called the Google of biological research, is one of the most widely used bioinformatics programs for sequence searching. It addresses a fundamental problem in bioinformatics research. The heuristic algorithm it uses is much faster than other approaches, such as calculating an optimal alignment. This emphasis on speed is vital to making the algorithm practical on the huge genome databases currently available, although subsequent algorithms can be even faster.