This time we are looking on the crossword clue for: Airhead.
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Possible Answers: SAP, DODO, LOON, YOYO, TWIT, DOLT, SIMP, DUNCE, NITWIT, DITZ, BIMBO, BIRDBRAIN, SPACECADET, DUMBBELL.
Last seen on: –The Washington Post Crossword – Apr 28 2019
–LA Times Crossword 28 Apr 19, Sunday
Random information on the term “SAP”:
4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
325
20219
ENSG00000132703
ENSMUSG00000026542
P02743
P12246
NM_001639
NM_011318
NP_001630
NP_035448.2
NP_035448
The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.
AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.
Random information on the term “YOYO”:
The 2013 World Yo-Yo Contest was the culminating yo-yo competition of the worldwide competitive circuit. The winners from this competition in any of the six championship divisions were deemed the current World Yo-Yo Champion until the 2014 World Champions were crowned. The competition was run by Gregory Cohen injunction with the International Yo-Yo Federation (IYYF). The competition took place at the Rozen Plaza Hotel in Orlando, Florida, USA from August 8–10, 2013.
The first World Yo-Yo Contest was held in London, England, in 1932. The winner was Harvey Lowe. However, the contest was not held annually until 1992, when Dale Oliver started one in Montreal, Canada during that year’s annual International Jugglers’ Association’s (IJA) convention. The contest was held during this convention until 1999, when it was held in Hawaii. The 2000 contest was held at Universal Studios in Orlando, but in 2001, the event moved to the Rosen Plaza Hotel, where it was held annually until 2013 by Gregory Cohen, owner and operator of YoYoGuy and Infinite Illusions. After the 2013 contest, an international coalition (the IYYF) was formed to organize a new, rotating contest which will be held in a different venue/country every year.
Random information on the term “TWIT”:
Coordinates: 38°16′35″N 122°40′03″W / 38.2764301°N 122.6676119°W / 38.2764301; -122.6676119
TWiT.tv, which is the operating trade name of TWiT LLC, is a podcast (although TWiT uses the term “netcast”) network founded by technology broadcaster and author Leo Laporte and run by his wife and company CEO Lisa Laporte. The network began operation in April 2005 with the launch of This Week in Tech. Security Now was the second podcast on the network, debuting in August of that year. Currently, the network hosts twenty-two podcasts and live streaming shows, including The Tech Guy, This Week in Tech, Security Now, FLOSS Weekly, MacBreak Weekly, Tech News Today, Tech News 2Night, and 15 other podcasts covering various topics including technology companies, computer security, social networking, and current technology news.
TWiT founder and owner Laporte, in an October 2009 speech, stated that it grossed revenues of $1.5 million per year, while costs were around $350,000. In November 2014, American Public Media’s Marketplace reported that TWiT makes $6 million in ad revenue a year from 5 million TWiT podcasts downloaded each month, mostly in the form of audio, and that 3,000 to 4,000 people watch its live-streamed shows. On March 18, 2015, prior to the filming of This Week in Google, Leo Laporte stated that TWiT expects to make $7 million in revenue in fiscal year 2015.
Random information on the term “SIMP”:
Weakly interacting massive particles (WIMPs) are hypothetical particles that are thought to constitute dark matter. There exists no clear definition of a WIMP, but broadly a WIMP is a new elementary particle which interacts via gravity and any other force (or forces), potentially not part of the standard model itself, which is as weak as or weaker than the weak nuclear force, but also non-vanishing in its strength. A WIMP must also have been produced thermally in the early Universe, similarly to the particles of the standard model according to Big Bang cosmology, and usually will constitute cold dark matter. Obtaining the correct abundance of dark matter today via thermal production requires a self-annihilation cross section of
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{\displaystyle \langle \sigma v\rangle \simeq 3\times 10^{-26}\mathrm {cm} ^{3}\;\mathrm {s} ^{-1}}
, which is roughly what is expected for a new particle in the 100 GeV mass range that interacts via the electroweak force. Because supersymmetric extensions of the standard model of particle physics readily predict a new particle with these properties, this apparent coincidence is known as the “WIMP miracle”, and a stable supersymmetric partner has long been a prime WIMP candidate. However, recent null results from direct detection experiments including LUX and SuperCDMS, along with the failure to produce evidence of supersymmetry in the Large Hadron Collider (LHC) experiment has cast doubt on the simplest WIMP hypothesis. Experimental efforts to detect WIMPs include the search for products of WIMP annihilation, including gamma rays, neutrinos and cosmic rays in nearby galaxies and galaxy clusters; direct detection experiments designed to measure the collision of WIMPs with nuclei in the laboratory, as well as attempts to directly produce WIMPs in colliders, such as the LHC.