An urge to scratch

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it’s A 18 letters crossword puzzle definition.
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Possible Answers:

ITCH.

Last seen on: Newsday.com Crossword – Apr 4 2022s

Random information on the term “ITCH”:

4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55

7852

12767

ENSG00000121966

ENSMUSG00000045382

P61073

P70658

NM_003467NM_001008540NM_001348056NM_001348059NM_001348060

NM_009911NM_001356509

NP_001008540NP_003458NP_001334985NP_001334988NP_001334989

NP_034041NP_001343438

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene. The protein is a CXC chemokine receptor.

CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency.

ITCH on Wikipedia