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Possible Answers: SON.
Last seen on: –Mirror Cryptic Crossword December 27 2022
Mirror Cryptic Crossword August 19 2017
Random information on the term “SON”:
6651
20658
ENSG00000159140
ENSMUSG00000022961
P18583
Q9QX47
NM_138927
NM_019973NM_178880
NP_001278340NP_001278341NP_115571NP_620305
NP_064357NP_849211
SON protein is a protein that in humans is encoded by the SON gene.
SON is the name that has been given to a large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. It is also known as BASS1 (Bax antagonist selected in saccharomyces 1) or NRE-binding protein (Negative regulatory element-binding protein). The most common gene name of this splicing protein- which is only found in Humans (Homo sapiens)- is SON, but C21orf50, DBP5, KIAA1019 and NREBP can also be used as synonyms.
The protein encoded by SON gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing.