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Possible Answers: EYESORE.
Last seen on: The Telegraph – Quick Crossword – Oct 24 2018
Random information on the term “Carbuncle”:
Staphylococcal scalded skin syndrome (SSSS), also known as pemphigus neonatorum or Ritter’s disease,[1] or localized bullous impetigo is a dermatological condition caused by Staphylococcus aureus.
The disease presents with the widespread formation of fluid-filled blisters that are thin walled and easily ruptured, and the patient can be positive for Nikolsky’s sign. Ritter’s disease of the newborn is the most severe form of SSSS, with similar signs and symptoms. SSSS often includes a widespread painful erythroderma, often involving the face, diaper, and other intertriginous areas. Extensive areas of desquamation might be present. Perioral crusting and fissuring are seen early in the course. Unlike toxic epidermal necrolysis, SSSS spares the mucous membranes. It is most common in children under 6 years, but can be seen in adults who are immunosuppressed or have renal failure.
The syndrome is induced by epidermolytic exotoxins (exfoliatin)[2] A and B, which are released by S. aureus and cause detachment within the epidermal layer, by breaking down the desmosomes. One of the exotoxins is encoded on the bacterial chromosome, while the other is encoded on a plasmid. These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together, similar to the pathophysiology of the autoimmune skin disease, pemphigus vulgaris.