This time we are looking on the crossword clue for: Deplete.
it’s A 7 letters crossword puzzle definition. See the possibilities below.
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Possible Answers: SAP, SPEND, EMPTY, DRAIN, USEUP, EATINTO, EXHAUST, USEBUP.
Last seen on: –Thomas Joseph – King Feature Syndicate Crossword – Apr 1 2024
–Thomas Joseph – King Feature Syndicate Crossword – May 15 2023
–USA Today Crossword – Mar 17 2023
–Wall Street Journal Crossword – December 06 2022 – Extreme Measures
–Thomas Joseph – King Feature Syndicate Crossword – Aug 20 2022
–Universal Crossword – Dec 16 2021
–LA Times Crossword 28 Aug 21, Saturday
–Universal Crossword – Aug 14 2021
–Universal Crossword – Aug 1 2021
–NY Times Crossword 2 Jun 21, Wednesday
–NY Times Crossword 29 Apr 21, Thursday
–Thomas Joseph – King Feature Syndicate Crossword – Feb 13 2021
–USA Today Crossword – Feb 6 2021
–USA Today Crossword – Dec 13 2020
–NY Times Crossword 21 Jul 20, Tuesday
–USA Today Crossword – Mar 23 2020
–Thomas Joseph – King Feature Syndicate Crossword – Oct 23 2019
–Universal Crossword – Dec 22 2018
–Newsday.com Crossword – Nov 20 2018
–Thomas Joseph – King Feature Syndicate Crossword – Oct 11 2018
–Premier Sunday – King Feature Syndicate Crossword – Sep 9 2018
Random information on the term “SAP”:
4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
325
20219
ENSG00000132703
ENSMUSG00000026542
P02743
P12246
NM_001639
NM_011318
NP_001630
NP_035448.2
NP_035448
The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.
AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.