Doofus

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Possible Answers: ASS, SAP, OAF, NERD, DODO, IDIOT, YOYO, DOPE, LOSER, CLOD, TWIT, DOLT, BOZO, SCHMO, BOOB, MORON, TWERP, SIMP, NINNY, DORK, NIMROD, DIMWIT, NINCOMPOOP, BONEHEAD, STUMBLEBUM, NOODLEHEAD, PUMPKINHEAD.

Last seen on: –NY Times Crossword 8 Dec 19, Sunday
The Washington Post Crossword – Jun 18 2019
NY Times Crossword 16 May 19, Thursday
New York Times Crossword – Feb 12 2019
Thomas Joseph – King Feature Syndicate Crossword – Jan 1 2019
Wall Street Journal Crossword – Oct 20 2018 – Little Monsters
The Washington Post Crossword – Sep 9 2018
LA Times Crossword 9 Sep 18, Sunday
NY Times Crossword 10 Jun 2018, Sunday
-Wall Street Journal Crossword – Nov 16 2017 – Shifting Gears

Random information on the term “ASS”:

The donkey or ass (Equus africanus asinus) is a domesticated member of the horse family, Equidae. The wild ancestor of the donkey is the African wild ass, E. africanus. The donkey has been used as a working animal for at least 5000 years. There are more than 40 million donkeys in the world, mostly in underdeveloped countries, where they are used principally as draught or pack animals. Working donkeys are often associated with those living at or below subsistence levels. Small numbers of donkeys are kept for breeding or as pets in developed countries.

A male donkey or ass is called a jack, a female a jenny or jennet; a young donkey is a foal. Jack donkeys are often used to mate with female horses to produce mules; the biological “reciprocal” of a mule, from a stallion and jenny as its parents instead, is called a hinny.

Asses were first domesticated around 3000 BC, probably in Egypt or Mesopotamia, and have spread around the world. They continue to fill important roles in many places today. While domesticated species are increasing in numbers, the African wild ass is an endangered species. As beasts of burden and companions, asses and donkeys have worked together with humans for millennia.

ASS on Wikipedia

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV

325

20219

ENSG00000132703

ENSMUSG00000026542

P02743

P12246

NM_001639

NM_011318

NP_001630

NP_035448.2
NP_035448

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.

SAP on Wikipedia

Random information on the term “OAF”:

In human–computer interaction, computer accessibility (also known as accessible computing) refers to the accessibility of a computer system to all people, regardless of disability type or severity of impairment. The term “accessibility” is most often used in reference to specialized hardware or software, or a combination of both, designed to enable use of a computer by a person with a disability or impairment. Specific technologies may be referred to as assistive technology.

There are many disabilities or impairments that can be a barrier to effective computer use. These impairments, which can be acquired from disease, trauma, or may be congenital, include but are not limited to:

Accessibility is often abbreviated as the numeronym a11y, where the number 11 refers to the number of letters omitted. This parallels the abbreviations of internationalization and localization as i18n and l10n respectively.

People wishing to overcome an impairment in order to use a computer comfortably and productively may require a “special needs assessment” by an assistive technology consultant (such as an occupational therapist, a rehabilitation engineering technologist, or an educational technologist) to help them identify and configure appropriate assistive technologies to meet individual needs. Even those who are unable to leave their own home or who live far from assessment providers may be assessed (and assisted) remotely using remote desktop software and a web cam. For example, the assessor logs on to the client’s computer via a broadband Internet connection, observes the users computer skills, and then remotely makes accessibility adjustments to the client’s computer where necessary.

OAF on Wikipedia

Random information on the term “NERD”:

N*E*R*D (a backronym of No-one Ever Really Dies) is an American funk rock band. Pharrell Williams and Chad Hugo were signed by Teddy Riley to Virgin Records as a duo, The Neptunes. After producing songs for several artists throughout the late 1990s and early 2000s, the production duo formed the band with Sarah Atyat Williams as a side project of The Neptunes in 1999. N*E*R*D’s debut album, In Search Of…, sold 603,000 copies in the United States and was certified Gold by the Recording Industry Association of America (RIAA). It was also awarded the second annual Shortlist Music Prize. The band’s second album, Fly or Die, sold 412,000 copies in the United States, but shipped at least 500,000 units, certifying it Gold.

In 2005, N*E*R*D ended their contract with Virgin and disbanded. Three years later, the band reunited under Star Trak Entertainment, a subsidiary of Interscope Records established by Williams and Hugo. The band’s third album, Seeing Sounds, released in 2008, sold just under 80,000 copies in its first week. The album was followed by Nothing, which was released in 2010.

NERD on Wikipedia

Random information on the term “YOYO”:

The 2013 World Yo-Yo Contest was the culminating yo-yo competition of the worldwide competitive circuit. The winners from this competition in any of the six championship divisions were deemed the current World Yo-Yo Champion until the 2014 World Champions were crowned. The competition was run by Gregory Cohen injunction with the International Yo-Yo Federation (IYYF). The competition took place at the Rozen Plaza Hotel in Orlando, Florida, USA from August 8–10, 2013.


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The first World Yo-Yo Contest was held in London, England, in 1932. The winner was Harvey Lowe. However, the contest was not held annually until 1992, when Dale Oliver started one in Montreal, Canada during that year’s annual International Jugglers’ Association’s (IJA) convention. The contest was held during this convention until 1999, when it was held in Hawaii. The 2000 contest was held at Universal Studios in Orlando, but in 2001, the event moved to the Rosen Plaza Hotel, where it was held annually until 2013 by Gregory Cohen, owner and operator of YoYoGuy and Infinite Illusions. After the 2013 contest, an international coalition (the IYYF) was formed to organize a new, rotating contest which will be held in a different venue/country every year.

YOYO on Wikipedia

Random information on the term “DOPE”:

This category has the following 8 subcategories, out of 8 total.

The following 186 pages are in this category, out of 186 total. This list may not reflect recent changes (learn more).

This category contains only the following file.

DOPE on Wikipedia

Random information on the term “CLOD”:

The beef clod or shoulder is one of the cheapest cuts of beef and is taken from the shoulder region of the cattle. This is why it is sometimes called chuck or shoulder clod, because obviously “chuck” or “clod” means cheap, apparently. Beef clod consists of a large muscle system and some fat that covers the muscles. Beef clod can be prepared in a variety of methods both dry and moist, but the most recommended method to cook beef clod is to cook it with moist heat or braising. Long slow smoking also provides acceptable results.

CLOD on Wikipedia

Random information on the term “TWIT”:

Coordinates: 38°16′35″N 122°40′03″W / 38.2764301°N 122.6676119°W / 38.2764301; -122.6676119

TWiT.tv, which is the operating trade name of TWiT LLC, is a podcast (although TWiT uses the term “netcast”) network founded by technology broadcaster and author Leo Laporte and run by his wife and company CEO Lisa Laporte. The network began operation in April 2005 with the launch of This Week in Tech. Security Now was the second podcast on the network, debuting in August of that year. Currently, the network hosts twenty-two podcasts and live streaming shows, including The Tech Guy, This Week in Tech, Security Now, FLOSS Weekly, MacBreak Weekly, Tech News Today, Tech News 2Night, and 15 other podcasts covering various topics including technology companies, computer security, social networking, and current technology news.

TWiT founder and owner Laporte, in an October 2009 speech, stated that it grossed revenues of $1.5 million per year, while costs were around $350,000. In November 2014, American Public Media’s Marketplace reported that TWiT makes $6 million in ad revenue a year from 5 million TWiT podcasts downloaded each month, mostly in the form of audio, and that 3,000 to 4,000 people watch its live-streamed shows. On March 18, 2015, prior to the filming of This Week in Google, Leo Laporte stated that TWiT expects to make $7 million in revenue in fiscal year 2015.

TWIT on Wikipedia

Random information on the term “SIMP”:

Weakly interacting massive particles (WIMPs) are hypothetical particles that are thought to constitute dark matter. There exists no clear definition of a WIMP, but broadly a WIMP is a new elementary particle which interacts via gravity and any other force (or forces), potentially not part of the standard model itself, which is as weak as or weaker than the weak nuclear force, but also non-vanishing in its strength. A WIMP must also have been produced thermally in the early Universe, similarly to the particles of the standard model according to Big Bang cosmology, and usually will constitute cold dark matter. Obtaining the correct abundance of dark matter today via thermal production requires a self-annihilation cross section of


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{\displaystyle \langle \sigma v\rangle \simeq 3\times 10^{-26}\mathrm {cm} ^{3}\;\mathrm {s} ^{-1}}

, which is roughly what is expected for a new particle in the 100 GeV mass range that interacts via the electroweak force. Because supersymmetric extensions of the standard model of particle physics readily predict a new particle with these properties, this apparent coincidence is known as the “WIMP miracle”, and a stable supersymmetric partner has long been a prime WIMP candidate. However, recent null results from direct detection experiments including LUX and SuperCDMS, along with the failure to produce evidence of supersymmetry in the Large Hadron Collider (LHC) experiment has cast doubt on the simplest WIMP hypothesis. Experimental efforts to detect WIMPs include the search for products of WIMP annihilation, including gamma rays, neutrinos and cosmic rays in nearby galaxies and galaxy clusters; direct detection experiments designed to measure the collision of WIMPs with nuclei in the laboratory, as well as attempts to directly produce WIMPs in colliders, such as the LHC.

SIMP on Wikipedia

Random information on the term “NIMROD”:

The cathode-ray tube amusement device is the earliest known interactive electronic game. The device simulates an artillery shell arcing towards targets on a cathode ray tube (CRT) screen, which is controlled by the player by adjusting knobs to change the trajectory of a CRT beam spot on the display in order to reach plastic targets overlaid on the screen. Thomas T. Goldsmith, Jr. and Estle Ray Mann constructed the game from analog electronics and filed for a patent in 1947, which was issued the following year. The gaming device was never manufactured or marketed to the public, so it had no effect on the future video game industry. Under most definitions, the device is not considered a video game, as while it had an electronic display it did not run on a computing device. Therefore, despite its relevance to the early history of video games, it is not generally considered a candidate for the title of first video game.

The cathode-ray tube amusement device consists of a cathode ray tube connected to an oscilloscope with a set of knobs and switches. The device uses purely analog electronics and does not use any digital computer or memory device or execute a program. The CRT projects a spot on the oscilloscope display screen, which traces a parabolic arc across the screen when a switch is activated by the player. This beam spot represents the trajectory of an artillery shell. Overlaid on the screen are transparent plastic targets representing objects such as airplanes. At the end of the spot’s trajectory, the beam defocuses, resulting in the spot expanding and blurring. This represents the shell exploding as if detonated by a time fuze. The goal of the game is to have the beam defocus when it is within the bounds of a target. Prior to the beam spot beginning its arc, the player can turn the control knobs to direct the beam spot’s trajectory and adjust the delay of the shell burst. The machine can be set to fire a “shell” either once or at a regular interval, which is adjustable by the player. This gives the player the goal of hitting one of the overlay targets with the shell burst within a time limit. The player was recommended to make the trajectory far removed from a straight line “so as to require an increased amount of skill and care”.

NIMROD on Wikipedia