This time we are looking on the crossword clue for: Drain.
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Possible Answers: TIRE, SAP, SEWER, EMPTY, USEUP, BLEED, SUMP, ENERVATE, DEPLETE, TIREOUT, EMPTYOUT, CULVERT.
Last seen on: –LA Times Crossword, Sat, Mar 30, 2024
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–Wall Street Journal Crossword – December 02 2022 – Floating Upstream
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–L.A. Times Daily Crossword – May 12 2022
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–Newsday.com Crossword – Apr 18 2019
–The Washington Post Crossword – Dec 1 2018
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–Newsday.com Crossword – Sep 1 2018
-The Washington Post Crossword – May 26 2018
-LA Times Crossword 26 May 2018, Saturday
Random information on the term “SAP”:
4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
325
20219
ENSG00000132703
ENSMUSG00000026542
P02743
P12246
NM_001639
NM_011318
NP_001630
NP_035448.2
NP_035448
The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.
AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.