This time we are looking on the crossword clue for: Enervate.
it’s A 8 letters crossword puzzle definition. See the possibilities below.
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Possible Answers: TIRE, SAP, UNMAN, WEAKEN.
Last seen on: –Eugene Sheffer – King Feature Syndicate Crossword – Feb 22 2024
–Eugene Sheffer – King Feature Syndicate Crossword – May 30 2023
–Eugene Sheffer – King Feature Syndicate Crossword – Jan 21 2023
–Eugene Sheffer – King Feature Syndicate Crossword – Oct 24 2022
–L.A. Times Daily Crossword – Feb 26 2022
–Eugene Sheffer – King Feature Syndicate Crossword – Mar 5 2021
–Eugene Sheffer – King Feature Syndicate Crossword – Nov 24 2020
–Eugene Sheffer – King Feature Syndicate Crossword – Mar 4 2020
–Eugene Sheffer – King Feature Syndicate Crossword – Jan 29 2020
–Eugene Sheffer – King Feature Syndicate Crossword – Nov 6 2019
–Eugene Sheffer – King Feature Syndicate Crossword – Jul 20 2019
–Eugene Sheffer – King Feature Syndicate Crossword – Jun 7 2019
–Eugene Sheffer – King Feature Syndicate Crossword – Mar 12 2019
–Premier Sunday – King Feature Syndicate Crossword – Jan 13 2019
Random information on the term “SAP”:
4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
325
20219
ENSG00000132703
ENSMUSG00000026542
P02743
P12246
NM_001639
NM_011318
NP_001630
NP_035448.2
NP_035448
The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.
AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.