Feel the pain

This time we are looking on the crossword clue for: Feel the pain.
it’s A 13 letters crossword puzzle definition. See the possibilities below.

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Possible Answers: ACHE, SMART, GRIEVE, SUFFER.

Last seen on: –NY Times Crossword 9 Nov 19, Saturday

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia

Random information on the term “SMART”:

S.M.A.R.T. (Self-Monitoring, Analysis and Reporting Technology; often written as SMART) is a monitoring system included in computer hard disk drives (HDDs) and solid-state drives (SSDs) that detects and reports on various indicators of drive reliability, with the intent of enabling the anticipation of hardware failures.

When S.M.A.R.T. data indicates a possible imminent drive failure, software running on the host system may notify the user so stored data can be copied to another storage device, preventing data loss, and the failing drive can be replaced.

Hard disk failures (and Flash drive failures, but not exactly in the same way) fall into one of two basic failure classes:

Mechanical failures account for about 60% of all drive failures. While the eventual failure may be catastrophic, most mechanical failures result from gradual wear and there are usually certain indications that failure is imminent. These may include increased heat output, increased noise level, problems with reading and writing of data, or an increase in the number of damaged disk sectors.

SMART on Wikipedia