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OUTBREAK.
Last seen on: Wall Street Journal Crossword – Mar 5 2019 – Former Lives
Random information on the term “Flare-up”:
An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin.[1] From Greek ἴδιος idios “one’s own” and πάθος pathos “suffering”, idiopathy means approximately “a disease of its own kind”. For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause may not be readily apparent or characterized. In these cases, the origin of the condition is said to be idiopathic. With some other medical conditions, the root cause for a large percentage of all cases have not been established—for example, focal segmental glomerulosclerosis or ankylosing spondylitis; the majority of these cases are deemed idiopathic.[2]
Advances in medical science improve the study of causes of diseases and the classification of diseases; thus, regarding any particular condition or disease, as more root causes are discovered, and as events that seemed spontaneous have their origins revealed, the percentage of cases designated as idiopathic decreases.