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Possible Answers:
CLOCK.
Last seen on: USA Today Crossword – Jul 19 2019
Random information on the term “CLOCK”:
4H10
406
11865
n/a
ENSMUSG00000055116
O00327
Q9WTL8
NM_001297724
NM_001243048NM_007489NM_001357070NM_001368412
NP_001284653NP_001338733NP_001338734NP_001338735NP_001338736NP_001338737NP_001338738NP_001338739NP_001338740NP_001338741NP_001338742NP_001338743NP_001338744NP_001338745NP_001338746NP_001338747NP_001338748NP_001338749NP_001338750NP_001338751NP_001338752NP_001338753
NP_001229977NP_031515NP_001343999NP_001355341
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the Bmal1 gene, also known as ARNTL, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC.
BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human Arntl gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that Bmal1 is the only clock gene without which the circadian clock fails to function in humans. Bmal1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in Bmal1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.