This time we are looking on the crossword clue for: Freeze.
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Possible Answers: ICE, STOP, HALT, ICEUP, STAYPUT, TENSEUP, CONGEAL, ICEOVER, DONTEVENBLINK.
Last seen on: –Newsday.com Crossword – Dec 19 2020
Random information on the term “ICE”:
1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA
834
12362
ENSG00000137752
ENSMUSG00000025888
P29466
P29452
NM_033294
NM_033295
NM_009807
NP_150636
NP_150637
NP_033937.2
NP_033937
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.
Random information on the term “STOP”:
In music, a double stop refers to the technique of playing two notes simultaneously on a bowed stringed instrument such as a violin, a viola, a cello, or a double bass. In performing a double stop, two separate strings are bowed or plucked simultaneously. Although the term itself suggests these strings are to be fingered (stopped), in practice one or both strings may be open.
A triple stop is the same technique applied to three strings; a quadruple stop applies to four strings. Double, triple, and quadruple stopping are collectively known as multiple stopping.
Early extensive examples of the double-stop and string chords appear in Carlo Farina’s Capriccio Stravagante from 1627, and in certain of the sonatas of Biagio Marini’s op. 8 of 1629.
On instruments with a curved bridge, it is difficult to bow more than two strings simultaneously. Early treatises make it clear that composers did not expect three notes to be played at once, even though the notes may be written in a way as to suggest this. Playing four notes at once is almost impossible. The normal way of playing three or four note chords is to sound the lower notes briefly and allow them to ring while the bow plays the upper notes (a broken chord). This gives the illusion of a true triple or quadruple stop. In forte, however, it is possible to play three notes at once, especially when bowed toward the fingerboard. With this technique more pressure than usual is needed on the bow, so this cannot be practiced in softer passages. This technique is mainly used in music with great force, such as the cadenza-like solo at the beginning of the last movement of Tchaikovsky’s violin concerto.
Random information on the term “HALT”:
A train station, railway station, railroad station, or depot (see below) is a railway facility where trains regularly stop to load or unload passengers or freight.
It generally consists of at least one track-side platform and a station building (depot) providing such ancillary services as ticket sales and waiting rooms. If a station is on a single-track line, it often has a passing loop to facilitate traffic movements. The smallest stations are most often referred to as “stops” or, in some parts of the world, as “halts” (flag stops).
Stations may be at ground level, underground, or elevated. Connections may be available to intersecting rail lines or other transport modes such as buses, trams or other rapid transit systems.
In the United Kingdom, traditional usage favours railway station or simply station, even though train station, which is often perceived as an Americanism, is now about as common as railway station in writing; railroad station is not used, railroad being obsolete there. In British usage, the word station is commonly understood to mean a railway station unless otherwise qualified.