Hand over

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Last seen on: –Thomas Joseph – King Feature Syndicate Crossword – May 29 2019
Thomas Joseph – King Feature Syndicate Crossword – Aug 8 2018

Random information on the term “CEDE”:

Thorotrast is a suspension containing particles of the radioactive compound thorium dioxide, ThO2, that was used as a radiocontrast agent in medical radiography in the 1930s and 1940s. (Use in some countries, such as the U.S., continued into the 1950s.)

Thorium compounds produce excellent images because of thorium’s high opacity to X-rays (it has a high cross section for absorption). Unfortunately, thorium is retained in the body, and it is radioactive, emitting harmful alpha radiation as it decays. Because the suspension offered high image quality and had virtually no immediate side-effects compared to the alternatives available at the time, Thorotrast became widely used after its introduction in 1931. (António Egas Moniz contributed to its development.). About 2 to 10 million patients worldwide have been treated with Thorotrast. However, today it has shown an increase risk in certain cancers such as cholangiocarcinomas and angiosarcomas of the liver.

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Even at the time of introduction, there was concern about the safety of Thorotrast. Following injection, the drug is distributed to the liver, spleen, lymph nodes, and bone, where it is absorbed. After this initial absorption, redistribution takes place at a very slow pace. Specifically, the biological half-life is estimated to be 22 years. This means that the organs of patients who have been given Thorotrast will be exposed to internal alpha radiation for the rest of their lives. The significance of this long-term exposure was not fully understood at the time of Thorotrast’s introduction in 1931.

CEDE on Wikipedia

Random information on the term “PRESENT”:

Metacritic is a website that aggregates reviews of media products: music albums, games, movies, TV shows, DVDs, and formerly, books. For each product, the scores from each review are averaged. Metacritic was created by Jason Dietz, Marc Doyle, and Julie Doyle Roberts. The site provides an excerpt from each review and hyperlinks to its source. A color of Green, Yellow or Red summarizes the critics’ recommendations and therefore the general appeal of the product to reviewers and, to a lesser extent, the public. It is regarded as the video game industry’s foremost review aggregator.

Metacritic’s scoring converts each review into a percentage, either mathematically from the mark given, or which the site decides subjectively from a qualitative review. Before being averaged, the scores are weighted according to the critic’s fame, stature, and volume of reviews.

Metacritic was launched in July 1999 by Marc Doyle, his sister Julie Doyle Roberts, and a classmate from the University of Southern California law school, Jason Dietz. Rotten Tomatoes was already compiling movie reviews, but Doyle, Roberts, and Dietz saw an opportunity to cover a broader range of media. They sold Metacritic to CNET in 2005. CNET and Metacritic are now owned by the CBS Corporation.

PRESENT on Wikipedia