Have a hankering

This time we are looking on the crossword clue for: Have a hankering.
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Possible Answers: ACHE, PINE, LONG, YEARN.

Last seen on: –Jonesin’ – Jun 18 2019
USA Today Crossword – Apr 10 2019

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia

Random information on the term “PINE”:

Alpine is a free software email client developed at the University of Washington.

Alpine is a rewrite of the Pine Message System that adds support for Unicode and other features. Alpine is meant to be suitable for both inexperienced email users and the most demanding of power users. Alpine can be learned by exploration and the use of context-sensitive help. The user interface can be customized.

Alpine shares many common features of console applications, like a rich set of shortcut keys, using keyboard instead of mouse to do all navigation and operation. In fact, all operations in Alpine have corresponding shortcut keys.

Unlike other console applications targeting developers and experienced users, which often require users to edit a configuration file, Alpine lets users change most configuration options within the software. This makes alpine one of the most easy to learn console-based email clients.

Alpine supports IMAP, POP, SMTP, NNTP and LDAP protocol natively. Although it does not support composing HTML email, it can display emails that only have HTML content as text. Alpine can read and write to folders in several formats, including Maildir, mbox, the mh format used by the mh message handling system, mbx, and mix.

PINE on Wikipedia