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Possible Answers:
NUMB.
Last seen on: Universal Crossword – May 16 2019
Random information on the term “NUMB”:
1WJ1
8650
18222
ENSG00000133961
ENSMUSG00000021224
P49757
Q9QZS3
NM_001005743NM_001005744NM_001005745NM_003744NM_001320114
NM_001136075NM_001272055NM_001272056NM_010949
NP_001005743NP_001005744NP_001005745NP_001307043NP_003735
NP_001129547NP_001258984NP_001258985NP_035079
Protein numb homolog is a protein that in humans is encoded by the NUMB gene.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved. Numb has been extensively studied in both invertebrates and mammals, though its function is best understood in Drosophila. Numb plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. During neurogenesis, Numb localizes to one side of the mother cell such that it is distributed selectively to one daughter cell. This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell.