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CORTISONE.
Last seen on: Cryptic crossword No 28,972
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A mood swing is an extreme or sudden change of mood. Such changes can play a positive part in promoting problem solving and in producing flexible forward planning, or be disruptive. When mood swings are severe, they may be categorized as part of a mental illness, such as bipolar disorder, where erratic and disruptive mood swings are a defining feature.
Mood swings can happen any time at any place, varying from the microscopic to the wild oscillations of bipolar disorder, so that a continuum can be traced from normal struggles around self-esteem, through cyclothymia, up to a depressive disease. However most people’s mood swings remain in the mild to moderate range of emotional ups and downs. The duration of bipolar mood swings also varies. They may last a few hours – ultrarapid – or extend over days – ultradian: clinicians maintain that only when four continuous days of hypomania, or seven days of mania, occur, is a diagnosis of bipolar disorder justified. In such cases, mood swings can extend over several days, even weeks: these episodes may consist of rapid alternation between feelings of depression and euphoria.
Hormone? My mood is being restricted (9) on Wikipedia