Hurt

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Possible Answers: ACHE, AIL, MAR, SORE, SMART, PAIN, HARM, ACHED, MAIM, STING, AILED, DAMAGE, OFFEND, WOUND, MAIMED, DAMAGED, PAINED, HARMED, SMARTED, INJURE, WOUNDED, INJURED.

Last seen on: –LA Times Crossword, Tue, Nov 7, 2023
Daily Boston Globe Crossword Sunday, 14 May 2023
The Sun – Two Speed Crossword – Jan 10 2021
NY Times Crossword 26 Dec 20, Saturday
NY Times Crossword 6 Sep 20, Sunday
Wall Street Journal Crossword – June 20 2020 – A Little Bit Country
Wall Street Journal Crossword – June 20 2020 – A Little Bit Country
NY Times Crossword 10 May 20, Sunday
Universal Crossword – May 8 2019
NY Times Crossword 16 Sep 18, Sunday
-The Telegraph – Quick Crossword – November 17 2017

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia

Random information on the term “AIL”:

A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the study of cause. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens, or it may be caused by internal dysfunctions particularly of the immune system such as an immunodeficiency, or a hypersensitivity including allergies and autoimmunity.

When caused by pathogens (i.e. Plasmodium ssp. in malaria), even in the scientific literature, the term disease is often misleadingly used in the place of its causal agent, viz. the pathogen. This language habitat can cause confusion in the communication of the cause-effect principle in epidemiology, and as such it should be strongly discouraged.

In humans, disease is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases can affect people not only physically, but also emotionally, as contracting and living with a disease can alter the affected person’s perspective on life.[citation needed]

AIL on Wikipedia

Random information on the term “MAR”:

West Syriac: Mor (as pronounced respectively in eastern and western dialects, from Syriac: ܡܪܝ‎ or East Syriac: Mar, Mār(y), written with a silent final yodh) is a title of respect in Syriac, literally meaning ‘my lord’. It is given to all saints and is also used before Christian name of bishops. The corresponding feminine form given to women saints is Mart or Mort (Syriac: ܡܪܬܝ‎, Mārt(y)). The title is placed before the Christian name, as in Mar Aprem/Mor Afrem and Mart/Mort Maryam.

The variant Maran or Moran (Syriac: ܡܪܢ‎, Māran), meaning “Our Lord”, is a particular title given to Jesus, either alone or in combination with other names and titles. Likewise, Martan or Mortan (Syriac: ܡܪܬܢ‎, Mārtan, “Our Lady”) is a title of Mary.

Occasionally, the term Maran or Moran has been used of various patriarchs and catholicoi. The Syriac Orthodox Patriarch of Antioch, the Malankara Orthodox Catholicos and the Syro-Malankara Major Archbishop Catholicos use the title Moran Mor. Sometimes the Indian bearers of this title are called Moran Mar, using a hybrid style from both Syriac dialects that reflects somewhat the history of Syrian Christians in Kerala. The Pope of Rome is referred to as Mar Papa by the Nasrani Saint Thomas Christians of India.

MAR on Wikipedia

Random information on the term “SMART”:

S.M.A.R.T. (Self-Monitoring, Analysis and Reporting Technology; often written as SMART) is a monitoring system included in computer hard disk drives (HDDs) and solid-state drives (SSDs) that detects and reports on various indicators of drive reliability, with the intent of enabling the anticipation of hardware failures.

When S.M.A.R.T. data indicates a possible imminent drive failure, software running on the host system may notify the user so stored data can be copied to another storage device, preventing data loss, and the failing drive can be replaced.

Hard disk failures (and Flash drive failures, but not exactly in the same way) fall into one of two basic failure classes:

Mechanical failures account for about 60% of all drive failures. While the eventual failure may be catastrophic, most mechanical failures result from gradual wear and there are usually certain indications that failure is imminent. These may include increased heat output, increased noise level, problems with reading and writing of data, or an increase in the number of damaged disk sectors.

SMART on Wikipedia

Random information on the term “PAIN”:

Suffering, or pain in a broad sense, may be an experience of unpleasantness and aversion associated with the perception of harm or threat of harm in an individual. Suffering is the basic element that makes up the negative valence of affective phenomena. The opposite of suffering is pleasure or happiness.

Suffering is often categorized as physical or mental. It may come in all degrees of intensity, from mild to intolerable. Factors of duration and frequency of occurrence usually compound that of intensity. Attitudes toward suffering may vary widely, in the sufferer or other people, according to how much it is regarded as avoidable or unavoidable, useful or useless, deserved or undeserved.

Suffering occurs in the lives of sentient beings in numerous manners, often dramatically. As a result, many fields of human activity are concerned with some aspects of suffering. These aspects may include the nature of suffering, its processes, its origin and causes, its meaning and significance, its related personal, social, and cultural behaviors, its remedies, management, and uses.

PAIN on Wikipedia

Random information on the term “HARM”:

The AGM-88 High-speed Anti-Radiation Missile (HARM) is a tactical, air-to-surface missile designed to home in on electronic transmissions coming from surface-to-air radar systems. It was originally developed by Texas Instruments as a replacement for the AGM-45 Shrike and AGM-78 Standard ARM system. Production was later taken over by Raytheon Corporation when it purchased the defense production business of Texas Instruments.

The AGM-88 can detect, attack and destroy a radar antenna or transmitter with minimal aircrew input. The proportional guidance system that homes in on enemy radar emissions has a fixed antenna and seeker head in the missile’s nose. A smokeless, solid-propellant, booster-sustainer rocket motor propels the missile at speeds over Mach 2. HARM, a U.S. Navy-led program, was initially integrated onto the A-6E, A-7 and F/A-18 and later onto the EA-6B. RDT&E for use on the F-14 was begun, but not completed. The USAF introduced HARM on the F-4G Wild Weasel and later on specialized F-16s equipped with the HARM Targeting System (HTS).

HARM on Wikipedia

Random information on the term “MAIM”:

Blinding is a type of physical punishment which results in complete or nearly complete loss of vision. It has been used as an act of vengeance and torture.

The method has been known since Antiquity. The Greek mythology makes several references to blinding as divine punishment, which reflects human practice. An example is Oedipus, who gouged out his own eyes after accidentally fulfilling the prophecy that he would end up killing his father and marrying his mother. In the Bible, Samson was blinded upon his capture by the Philistines.

Early Christians were often blinded as a penalty for their beliefs. For example, St. Lucy’s torturers tore out her eyes. In the Middle Ages, blinding was used as a penalty for treachery or as a means of rendering a political opponent unable to rule and lead an army in war. In the 11th century, William the Conqueror used blinding as a punishment for rebellion to replace the death penalty in his laws for England; it was also used as punishment for killing a hart or hind in a royal forest. Henry I of England blinded William, Count of Mortain, who had fought against him at Tinchebray in 1106. He also ordered blinding and castration as a punishment for thieves. In 1014, the Byzantine emperor Basil II had 99 of every 100 captured Bulgarians blinded, leaving 150 one-eyed men to lead them back to their commander. Blinding was accomplished by gouging out the eyes, sometimes using a hot poker, and by pouring a boiling substance, such as vinegar, on them.

MAIM on Wikipedia

Random information on the term “STING”:

Cognitive genomics (or neurative genomics) is the sub-field of genomics pertaining to cognitive function in which the genes and non-coding sequences of an organism’s genome related to the health and activity of the brain are studied. By applying comparative genomics, the genomes of multiple species are compared in order to identify genetic and phenotypical differences between species. Observed phenotypical characteristics related to the neurological function include behavior, personality, neuroanatomy, and neuropathology. The theory behind cognitive genomics is based on elements of genetics, evolutionary biology, molecular biology, cognitive psychology, behavioral psychology, and neurophysiology.

Intelligence is the most extensively studied behavioral trait. In humans, approximately 70% of all genes are expressed in the brain. Genetic variation accounts for 40% of phenotypical variation. Approaches in cognitive genomics have been used to investigate the genetic causes for many mental and neurodegenerative disorders including Down syndrome, Major Depressive Disorder, autism, and Alzheimer’s disease.

STING on Wikipedia