It controls the central nervous system

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Possible Answers: BRAIN.

Last seen on: Irish Times Simplex Crossword – Sep 19 2018

Random information on the term “BRAIN”:

The Brain is a 1962 science fiction thriller film directed by Freddie Francis, and starring Anne Heywood and Peter van Eyck.[1] A UK-West German production (also released as Ein Toter sucht seinen Mörder)

The Brain differs from earlier film versions of the Curt Siodmak novel Donovan’s Brain: in this remake, the dead man seeks his own murderer through contact with the doctor keeping his brain alive.[2]

BRAIN on Wikipedia