It’s used in soapmaking

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Possible Answers:

LYE.

Last seen on: NY Times Crossword 10 Feb 21, Wednesday

Random information on the term “LYE”:

Bases are defined by the Brønsted–Lowry theory as chemical substances that can accept a proton, i.e., a hydrogen ion. In water this is equivalent to a hydronium ion). The Lewis theory instead defines a Base as an electron-pair donor. The Lewis definition is broader — all Brønsted–Lowry bases are also Lewis bases.

For more information see acid–base reaction theories.

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LYE on Wikipedia