John in ‘Atlas Shrugged’

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Possible Answers: GALT.

Last seen on: Eugene Sheffer – King Feature Syndicate Crossword – Aug 13 2018

Random information on the term “GALT”:

5IN3

2592

14430

ENSG00000213930

ENSMUSG00000036073

P07902

Q03249

NM_001258332NM_000155

NM_016658NM_001302511

NP_000146NP_001245261

NP_001289440NP_057867

Galactose-1-phosphate uridylyltransferase (or GALT) is an enzyme (EC 2.7.7.12) responsible for converting ingested galactose to glucose.[5]

Galactose-1-phosphate uridylyltransferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely:

The expression of GALT is controlled by the actions of the FOXO3 gene. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined.[5]

galactose

glucose

GALT catalyzes the second reaction of the Leloir pathway of galactose metabolism through ping pong bi-bi kinetics with a double displacement mechanism.[6] This means that the net reaction consists of two reactants and two products (see the reaction above) and it proceeds by the following mechanism: the enzyme reacts with one substrate to generate one product and a modified enzyme, which goes on to react with the second substrate to make the second product while regenerating the original enzyme.[7] In the case of GALT, the His166 residue acts as a potent nucleophile to facilitate transfer of a nucleotide between UDP-hexoses and hexose-1-phosphates.[8]

GALT on Wikipedia