This time we are looking on the crossword clue for: Joint problem.
it’s A 13 letters crossword puzzle definition. See the possibilities below.
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Possible Answers: ACHE, GOUT, ARTHRITIS.
Random information on the term “ACHE”:
An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
Some major effects of cholinesterase inhibitors:
Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.
When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).