Now we are looking on the crossword clue for: "Keep it down!".
it’s A 23 letters crossword puzzle definition.
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Possible Answers:
SHH.
Last seen on: Eugene Sheffer – King Feature Syndicate Crossword – Feb 16 2022
Random information on the term “"Keep it down!"”:
E, or e, is the fifth letter and the second vowel letter in the modern English alphabet and the ISO basic Latin alphabet. Its name in English is e (pronounced /ˈiː/); plural ees, Es or E’s. It is the most commonly used letter in many languages, including Czech, Danish, Dutch, English, French, German, Hungarian, Latin, Latvian, Norwegian, Spanish, and Swedish.
hillul
The Latin letter ‘E’ differs little from its source, the Greek letter epsilon, ‘Ε’. This in turn comes from the Semitic letter hê, which has been suggested to have started as a praying or calling human figure (hillul ‘jubilation’), and was most likely based on a similar Egyptian hieroglyph that indicated a different pronunciation. In Semitic, the letter represented /h/ (and /e/ in foreign words); in Greek, hê became the letter epsilon, used to represent /e/. The various forms of the Old Italic script and the Latin alphabet followed this usage.
Random information on the term “SHH”:
3HO5, 3M1N, 3MXW
6469
20423
ENSG00000164690
ENSMUSG00000002633
Q15465
Q62226
NM_000193NM_001310462
NM_009170
NP_000184NP_001297391
NP_033196
Sonic hedgehog is a protein encoded for by the SHH gene. The protein is named after the video game character Sonic the Hedgehog.
This signaling molecule is key in regulating embryonic morphogenesis in all different types of animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French Flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted.