Med. lab letters

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Possible Answers:

LDL.

Last seen on: LA Times Crossword 10 Mar 19, Sunday

Random information on the term “LDL”:

2P4E, 2PMW, 2QTW, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 2XTJ, 3BPS, 3GCW, 3GCX, 3H42, 3M0C, 3P5B, 3P5C, 3SQO, 4K8R, 4NE9, 4NMX, 4OV6

255738

100102

ENSG00000169174

ENSMUSG00000044254

Q8NBP7

Q80W65

NM_174936

NM_153565

NP_777596

NP_705793


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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.[5] It is the 9th member of the proprotein convertase family of proteins that activate other proteins.[6] Similar genes (orthologs) are found across many species. As with many proteins, PCSK9 is inactive when first synthesized, because a section of peptide chains blocks their activity; proprotein convertases remove that section to activate the enzyme.[7] The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.[8]

PCSK9 is ubiquitously expressed in many tissues and cell types.[9] PCSK9 binds to the receptor for low-density lipoprotein particles (LDL), which typically transport 3,000 to 6,000 fat molecules (including cholesterol) per particle, within extracellular fluid. The LDL receptor (LDLR), on liver and other cell membranes, binds and initiates ingestion of LDL-particles from extracellular fluid into cells, thus reducing LDL particle concentrations. If PCSK9 is blocked, more LDLRs are recycled and are present on the surface of cells to remove LDL-particles from the extracellular fluid.[10] Therefore, blocking PCSK9 can lower blood LDL-particle concentrations.[11][12]

LDL on Wikipedia