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Last seen on: –NY Times Crossword 11 Aug 20, Tuesday
Wall Street Journal Crossword – May 06 2020 – I Repeat
Wall Street Journal Crossword – April 22 2020 – Offensive Line
NY Times Crossword 29 Dec 19, Sunday
LA Times Crossword 1 Nov 19, Friday
Wall Street Journal Crossword – August 26 2019 – Championship Run
LA Times Crossword 17 Jun 19, Monday
The Washington Post Crossword – Jun 17 2019
NY Times Crossword 4 Dec 18, Tuesday
Wall Street Journal Crossword – Oct 10 2018 – Boy Wander
The Washington Post Crossword – Oct 3 2018
LA Times Crossword 3 Oct 18, Wednesday
NY Times Crossword 20 Jun 2018, Wednesday
-LA Times Crossword 27 May 2018, Sunday
-The Washington Post Crossword – May 27 2018

Random information on the term “ASS”:

The donkey or ass (Equus africanus asinus) is a domesticated member of the horse family, Equidae. The wild ancestor of the donkey is the African wild ass, E. africanus. The donkey has been used as a working animal for at least 5000 years. There are more than 40 million donkeys in the world, mostly in underdeveloped countries, where they are used principally as draught or pack animals. Working donkeys are often associated with those living at or below subsistence levels. Small numbers of donkeys are kept for breeding or as pets in developed countries.

A male donkey or ass is called a jack, a female a jenny or jennet; a young donkey is a foal. Jack donkeys are often used to mate with female horses to produce mules; the biological “reciprocal” of a mule, from a stallion and jenny as its parents instead, is called a hinny.

Asses were first domesticated around 3000 BC, probably in Egypt or Mesopotamia, and have spread around the world. They continue to fill important roles in many places today. While domesticated species are increasing in numbers, the African wild ass is an endangered species. As beasts of burden and companions, asses and donkeys have worked together with humans for millennia.

ASS on Wikipedia

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV











The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.

SAP on Wikipedia

Random information on the term “OAF”:

In human–computer interaction, computer accessibility (also known as accessible computing) refers to the accessibility of a computer system to all people, regardless of disability type or severity of impairment. The term “accessibility” is most often used in reference to specialized hardware or software, or a combination of both, designed to enable use of a computer by a person with a disability or impairment. Specific technologies may be referred to as assistive technology.

There are many disabilities or impairments that can be a barrier to effective computer use. These impairments, which can be acquired from disease, trauma, or may be congenital, include but are not limited to:

Accessibility is often abbreviated as the numeronym a11y, where the number 11 refers to the number of letters omitted. This parallels the abbreviations of internationalization and localization as i18n and l10n respectively.

People wishing to overcome an impairment in order to use a computer comfortably and productively may require a “special needs assessment” by an assistive technology consultant (such as an occupational therapist, a rehabilitation engineering technologist, or an educational technologist) to help them identify and configure appropriate assistive technologies to meet individual needs. Even those who are unable to leave their own home or who live far from assessment providers may be assessed (and assisted) remotely using remote desktop software and a web cam. For example, the assessor logs on to the client’s computer via a broadband Internet connection, observes the users computer skills, and then remotely makes accessibility adjustments to the client’s computer where necessary.

OAF on Wikipedia

Random information on the term “DOPE”:

This category has the following 8 subcategories, out of 8 total.

The following 186 pages are in this category, out of 186 total. This list may not reflect recent changes (learn more).

This category contains only the following file.

DOPE on Wikipedia

Random information on the term “TWIT”:

Coordinates: 38°16′35″N 122°40′03″W / 38.2764301°N 122.6676119°W / 38.2764301; -122.6676119, which is the operating trade name of TWiT LLC, is a podcast (although TWiT uses the term “netcast”) network founded by technology broadcaster and author Leo Laporte and run by his wife and company CEO Lisa Laporte. The network began operation in April 2005 with the launch of This Week in Tech. Security Now was the second podcast on the network, debuting in August of that year. Currently, the network hosts twenty-two podcasts and live streaming shows, including The Tech Guy, This Week in Tech, Security Now, FLOSS Weekly, MacBreak Weekly, Tech News Today, Tech News 2Night, and 15 other podcasts covering various topics including technology companies, computer security, social networking, and current technology news.

TWiT founder and owner Laporte, in an October 2009 speech, stated that it grossed revenues of $1.5 million per year, while costs were around $350,000. In November 2014, American Public Media’s Marketplace reported that TWiT makes $6 million in ad revenue a year from 5 million TWiT podcasts downloaded each month, mostly in the form of audio, and that 3,000 to 4,000 people watch its live-streamed shows. On March 18, 2015, prior to the filming of This Week in Google, Leo Laporte stated that TWiT expects to make $7 million in revenue in fiscal year 2015.

TWIT on Wikipedia

Random information on the term “HEAD”:

Shock Stop is a system developed by sports equipment manufacturer Head to damp (reduce) vibration in its range of titanium tennis rackets. It works by drawing the vibration down the frame of the racket into the handle, where a ball-bearing balanced mechanism absorbs the shock.

Head’s latest vibration dampening system is EDS (Electronic Dampening System) which is being implemented into the newer rackets, such as the HEAD Protector. It works by using piezoelectric fibers, which convert mechanical into electronic energy, controlled by a microchip. EDS recognizes the damping mode and electronically creates a cancelling counter vibration. This reduces shock impact by more than 50% and residual vibrations twice as fast as in a conventional racquet period.

HEAD on Wikipedia

Random information on the term “FOOL”:

Nationale Regionale Transport is a domestic airline based in Libreville, Gabon. Its main base is Libreville International Airport. It was rebranded in 2009 from National Airways Gabon.

The airline is on the list of air carriers banned in the European Union.

The Nationale Regionale Transport fleet includes the following aircraft (as of February 2014):

Nationale Regionale Transport has also operated the following aircraft:

FOOL on Wikipedia

Random information on the term “SIMP”:

Weakly interacting massive particles (WIMPs) are hypothetical particles that are thought to constitute dark matter. There exists no clear definition of a WIMP, but broadly a WIMP is a new elementary particle which interacts via gravity and any other force (or forces), potentially not part of the standard model itself, which is as weak as or weaker than the weak nuclear force, but also non-vanishing in its strength. A WIMP must also have been produced thermally in the early Universe, similarly to the particles of the standard model according to Big Bang cosmology, and usually will constitute cold dark matter. Obtaining the correct abundance of dark matter today via thermal production requires a self-annihilation cross section of









{\displaystyle \langle \sigma v\rangle \simeq 3\times 10^{-26}\mathrm {cm} ^{3}\;\mathrm {s} ^{-1}}

, which is roughly what is expected for a new particle in the 100 GeV mass range that interacts via the electroweak force. Because supersymmetric extensions of the standard model of particle physics readily predict a new particle with these properties, this apparent coincidence is known as the “WIMP miracle”, and a stable supersymmetric partner has long been a prime WIMP candidate. However, recent null results from direct detection experiments including LUX and SuperCDMS, along with the failure to produce evidence of supersymmetry in the Large Hadron Collider (LHC) experiment has cast doubt on the simplest WIMP hypothesis. Experimental efforts to detect WIMPs include the search for products of WIMP annihilation, including gamma rays, neutrinos and cosmic rays in nearby galaxies and galaxy clusters; direct detection experiments designed to measure the collision of WIMPs with nuclei in the laboratory, as well as attempts to directly produce WIMPs in colliders, such as the LHC.

SIMP on Wikipedia