Nitwit

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Possible Answers: ASS, SAP, DODO, IDIOT, DOPE, CLOD, DOLT, FOOL, BOZO, COOT, BOOB, MORON, STUPE, SIMP, DINGBAT, PINHEAD, BIRDBRAIN, FATHEAD, LAMEBRAIN, MEATHEAD, DOP, BONEHEAD, DUMDUM, BLOCKHEAD, CHUCKLEHEAD.

Last seen on: –Eugene Sheffer – King Feature Syndicate Crossword – Mar 20 2019
Wall Street Journal Crossword – Mar 5 2019 – Former Lives
The Washington Post Crossword – Feb 15 2019
LA Times Crossword 15 Feb 19, Friday
Eugene Sheffer – King Feature Syndicate Crossword – Jan 21 2019
Eugene Sheffer – King Feature Syndicate Crossword – Dec 11 2018
The Sun – Two Speed Crossword – Dec 8 2018
Eugene Sheffer – King Feature Syndicate Crossword – Dec 1 2018
Eugene Sheffer – King Feature Syndicate Crossword – Oct 20 2018
Eugene Sheffer – King Feature Syndicate Crossword – Oct 15 2018

Random information on the term “ASS”:

The donkey or ass (Equus africanus asinus) is a domesticated member of the horse family, Equidae. The wild ancestor of the donkey is the African wild ass, E. africanus. The donkey has been used as a working animal for at least 5000 years. There are more than 40 million donkeys in the world, mostly in underdeveloped countries, where they are used principally as draught or pack animals. Working donkeys are often associated with those living at or below subsistence levels. Small numbers of donkeys are kept for breeding or as pets in developed countries.

A male donkey or ass is called a jack, a female a jenny or jennet; a young donkey is a foal. Jack donkeys are often used to mate with female horses to produce mules; the biological “reciprocal” of a mule, from a stallion and jenny as its parents instead, is called a hinny.

Asses were first domesticated around 3000 BC, probably in Egypt or Mesopotamia, and have spread around the world. They continue to fill important roles in many places today. While domesticated species are increasing in numbers, the African wild ass is an endangered species. As beasts of burden and companions, asses and donkeys have worked together with humans for millennia.

ASS on Wikipedia

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV

325

20219

ENSG00000132703

ENSMUSG00000026542

P02743

P12246

NM_001639

NM_011318

NP_001630

NP_035448.2
NP_035448

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.


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SAP on Wikipedia

Random information on the term “DOPE”:

This category has the following 8 subcategories, out of 8 total.

The following 186 pages are in this category, out of 186 total. This list may not reflect recent changes (learn more).

This category contains only the following file.

DOPE on Wikipedia

Random information on the term “CLOD”:

The beef clod or shoulder is one of the cheapest cuts of beef and is taken from the shoulder region of the cattle. This is why it is sometimes called chuck or shoulder clod, because obviously “chuck” or “clod” means cheap, apparently. Beef clod consists of a large muscle system and some fat that covers the muscles. Beef clod can be prepared in a variety of methods both dry and moist, but the most recommended method to cook beef clod is to cook it with moist heat or braising. Long slow smoking also provides acceptable results.

CLOD on Wikipedia

Random information on the term “FOOL”:

Nationale Regionale Transport is a domestic airline based in Libreville, Gabon. Its main base is Libreville International Airport. It was rebranded in 2009 from National Airways Gabon.

The airline is on the list of air carriers banned in the European Union.

The Nationale Regionale Transport fleet includes the following aircraft (as of February 2014):

Nationale Regionale Transport has also operated the following aircraft:

FOOL on Wikipedia

Random information on the term “SIMP”:

Weakly interacting massive particles (WIMPs) are hypothetical particles that are thought to constitute dark matter. There exists no clear definition of a WIMP, but broadly a WIMP is a new elementary particle which interacts via gravity and any other force (or forces), potentially not part of the standard model itself, which is as weak as or weaker than the weak nuclear force, but also non-vanishing in its strength. A WIMP must also have been produced thermally in the early Universe, similarly to the particles of the standard model according to Big Bang cosmology, and usually will constitute cold dark matter. Obtaining the correct abundance of dark matter today via thermal production requires a self-annihilation cross section of


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v


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×

10


26

c
m

3

s


1

{\displaystyle \langle \sigma v\rangle \simeq 3\times 10^{-26}\mathrm {cm} ^{3}\;\mathrm {s} ^{-1}}

, which is roughly what is expected for a new particle in the 100 GeV mass range that interacts via the electroweak force. Because supersymmetric extensions of the standard model of particle physics readily predict a new particle with these properties, this apparent coincidence is known as the “WIMP miracle”, and a stable supersymmetric partner has long been a prime WIMP candidate. However, recent null results from direct detection experiments including LUX and SuperCDMS, along with the failure to produce evidence of supersymmetry in the Large Hadron Collider (LHC) experiment has cast doubt on the simplest WIMP hypothesis. Experimental efforts to detect WIMPs include the search for products of WIMP annihilation, including gamma rays, neutrinos and cosmic rays in nearby galaxies and galaxy clusters; direct detection experiments designed to measure the collision of WIMPs with nuclei in the laboratory, as well as attempts to directly produce WIMPs in colliders, such as the LHC.

SIMP on Wikipedia

Random information on the term “DOP”:

Data-oriented parsing (DOP, also data-oriented processing) is a probabilistic model in computational linguistics. DOP was conceived by Remko Scha in 1990 with the aim of developing a performance-oriented grammar framework. Unlike other probabilistic models, DOP takes into account all subtrees contained in a treebank rather than being restricted to, for example, 2-level subtrees (like PCFGs).

Several variants of DOP have been developed. The initial version developed by Rens Bod was based on tree-substitution grammar, while more recently, DOP has been combined with lexical-functional grammar (LFG). The resulting DOP-LFG finds an application in machine translation. Other work on learning and parameter estimation for DOP has also found its way into machine translation.

DOP on Wikipedia