NON

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Possible Answers: ACHE.

Last seen on: –NY Times Crossword 9 Aug 20, Sunday
NY Times Crossword 18 Oct 18, Thursday
-USA Today Crossword – November 25 2017 Saturday Crossword Answers
USA Today Crossword – November 25 2017 Saturday Crossword Answers

Random information on the term “NON”:

French (le français [lə fʁɑ̃sɛ] ( listen) or la langue française [la lɑ̃ɡ fʁɑ̃sɛz]) is a Romance language of the Indo-European family. It descended from the Vulgar Latin of the Roman Empire, as did all Romance languages. French has evolved from Gallo-Romance, the spoken Latin in Gaul, and more specifically in Northern Gaul. Its closest relatives are the other langues d’oïl—languages historically spoken in northern France and in southern Belgium, which French (Francien) has largely supplanted. French was also influenced by native Celtic languages of Northern Roman Gaul like Gallia Belgica and by the (Germanic) Frankish language of the post-Roman Frankish invaders. Today, owing to France’s past overseas expansion, there are numerous French-based creole languages, most notably Haitian Creole. A French-speaking person or nation may be referred to as “Francophone” in both English and French.

French is an official language in 29 countries across five different continents, most of which are members of the Organisation internationale de la Francophonie (OIF), the community of 84 countries which share the official use or teaching of French. It is spoken as a first language (in descending order of the highest number) in France, the Canadian provinces of Quebec and New Brunswick, the regions of Wallonia and Brussels in Belgium, western Switzerland, Monaco, certain other regions of Canada and the United States (Louisiana and the northern parts of Maine, New Hampshire, and Vermont), and by various communities elsewhere. In 2015, approximately 40% of the francophone population (including L2 and partial speakers) lived in Europe, 35% in sub-Saharan Africa, 15% in North Africa and the Middle East, 8% in the Americas, and 1% in Asia and Oceania.

NON on Wikipedia

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia