Now we are looking on the crossword clue for: Orth of TV’s ‘Revolution’.
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Possible Answers: ZAK.
Last seen on: Wall Street Journal Crossword – Aug 19 2017 – Sleep Over
Random information on the term “ZAK”:
4ZRK, 5BRK, 5B5W
9113
16798
ENSG00000131023
ENSMUSG00000040021
O95835Q6PJG3
Q8BYR2
NM_001270519NM_004690NM_001350339NM_001350340NM_001350392
NM_010690
NP_001257448NP_004681NP_001337268NP_001337269NP_001337321
NP_034820
Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.
It has been associated with the Hippo signaling pathway.
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.