Pain in the neck

This time we are looking on the crossword clue for: Pain in the neck.
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Possible Answers: ACHE, PEST, DRAG, TWIT, PILL, HASSLE, KINK, NUISANCE, CRICK, IRRITANT, ANNOYANCE, IRRITATION.

Last seen on: –Wall Street Journal Crossword – Jan 5 2019 – Shaken, Not Stirred
Wall Street Journal Crossword – May 30 2018 – Inner Nerd

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia

Random information on the term “PEST”:

PEST analysis (political, economic, social and technological) describes a framework of macro-environmental factors used in the environmental scanning component of strategic management. It is part of an external analysis when conducting a strategic analysis or doing market research, and gives an overview of the different macro-environmental factors to be taken into consideration. It is a strategic tool for understanding market growth or decline, business position, potential and direction for operations.

Variants that build on the PEST framework include:

There is also STEER, which considers socio-cultural, technological, economic, ecological, and regulatory factors, but does not specifically include political factors.

The basic PEST analysis includes four factors:

Expanding the analysis to PESTLE or PESTEL adds:

Other factors for the various offshoots include:

More factors discussed in the SPELIT Power Matrix include:

The model’s factors will vary in importance to a given company based on its industry and the goods it produces. For example, consumer and B2B companies tend to be more affected by the social factors, while a global defense contractor would tend to be more affected by political factors. Additionally, factors that are more likely to change in the future or more relevant to a given company will carry greater importance. For example, a company which has borrowed heavily will need to focus more on the economic factors (especially interest rates).


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PEST on Wikipedia

Random information on the term “TWIT”:

Coordinates: 38°16′35″N 122°40′03″W / 38.2764301°N 122.6676119°W / 38.2764301; -122.6676119

TWiT.tv, which is the operating trade name of TWiT LLC, is a podcast (although TWiT uses the term “netcast”) network founded by technology broadcaster and author Leo Laporte and run by his wife and company CEO Lisa Laporte. The network began operation in April 2005 with the launch of This Week in Tech. Security Now was the second podcast on the network, debuting in August of that year. Currently, the network hosts twenty-two podcasts and live streaming shows, including The Tech Guy, This Week in Tech, Security Now, FLOSS Weekly, MacBreak Weekly, Tech News Today, Tech News 2Night, and 15 other podcasts covering various topics including technology companies, computer security, social networking, and current technology news.

TWiT founder and owner Laporte, in an October 2009 speech, stated that it grossed revenues of $1.5 million per year, while costs were around $350,000. In November 2014, American Public Media’s Marketplace reported that TWiT makes $6 million in ad revenue a year from 5 million TWiT podcasts downloaded each month, mostly in the form of audio, and that 3,000 to 4,000 people watch its live-streamed shows. On March 18, 2015, prior to the filming of This Week in Google, Leo Laporte stated that TWiT expects to make $7 million in revenue in fiscal year 2015.

TWIT on Wikipedia

Random information on the term “HASSLE”:

This category has the following 15 subcategories, out of 15 total.

The following 178 pages are in this category, out of 178 total. This list may not reflect recent changes (learn more).

HASSLE on Wikipedia

Random information on the term “KINK”:

Portland International Airport (IATA: PDX, ICAO: KPDX, FAA LID: PDX) is a joint civil-military airport and the largest airport in the U.S. state of Oregon, accounting for 90 percent of passenger travel and more than 95 percent of air cargo of the state. It is located within Portland’s city limits just south of the Columbia River in Multnomah County, 6 miles (10 kilometers) by air and 12 mi (19 km) by highway northeast of Downtown Portland. Portland International Airport is often referred to by its IATA airport code, PDX.

Portland International Airport has direct flights and connections to most major airports throughout the United States, and non-stop international flights to Canada, Germany, Iceland, Japan, Mexico, the Netherlands and the United Kingdom. The airport is a secondary hub for Alaska Airlines and Horizon Air, with Seattle–Tacoma International Airport as the primary hub for Alaska Airlines and Horizon Air. The airport also serves as a maintenance facility for Horizon Air. Regional carrier PenAir operate their Pacific Northwest hub at PDX. General aviation services are provided at PDX by Atlantic Aviation. The Oregon Air National Guard has a base located on the southwest portion of the airport property grounds, and is also the host unit of the 142d Fighter Wing (142 FW) and the F-15 Eagle. Local transportation includes the MAX Red Line light rail, which takes passengers between PDX and Downtown Portland, as well as farther west to Beaverton, Oregon. There is also Interstate 205, which connects to southwestern Washington (north from PDX) along with many suburbs of Portland (south from PDX).

KINK on Wikipedia