Past ___ (like an unpaid bill)

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Possible Answers:

Due.

Last seen on: Daily Celebrity Crossword – 2/24/19 People Sunday

Random information on the term “Due”:

A DNA unwinding element (DUE or DNAUE) is the initiation site for the opening of the double helix structure of the DNA at the origin of replication for DNA synthesis.[1] It is A-T rich and denatures easily due to its low helical stability,[2] which allows the single-strand region to be recognized by origin recognition complex.

DUEs are found in both prokaryotic and eukaryotic organisms, but were first discovered in yeast and bacteria origins, by Huang Kowalski.[3][4] The DNA unwinding allows for access of replication machinery to the newly single strands.[1] In eukaryotes, DUEs are the binding site for DNA-unwinding element binding (DUE-B) proteins required for replication initiation.[3] In prokaryotes, DUEs are found in the form of tandem consensus sequences flanking the 5′ end of DnaA binding domain.[2] The act of unwinding at these A-T rich elements occurs even in absence of any origin binding proteins due to negative supercoiling forces, making it an energetically favourable action.[2] DUEs are typically found spanning 30-100 bp of replication origins.[4][5]

Due on Wikipedia