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Possible Answers: SON.
Last seen on: LA Times Crossword 10 Jul 2018, Tuesday
Random information on the term “Prodigal __”:
Prodigals is a play (2011) by Sean Minogue about a group of twenty-somethings in Sault Ste. Marie, Ontario who spend their days drinking in a bar while awaiting the results of a friend’s murder trial.
The play premiered in May 2011 in Vancouver, British Columbia as the first original production of the Twenty-Something Theatre company.[1] Described as a “notable accomplishment” by one critic[2] and “an impressive and polished first play” by another,[3] the premiere was directed by Peter Boychuk, produced by Sabrina Evertt, and featured Tara Pratt as Jen, Timothy Johnston as Wesley, Jameson Parker as Greg, Brandyn Eddy as Nips, Aslam Husain as Eliot, and Kirsten Kilburn as Nina.
A workshop production was previously produced in May 2010 at Vancouver’s Havana restaurant and theatre,[4] which also elicited positive reactions from critics.[5]
Minogue adapted his play into a feature screenplay[6][7] and sold the option to Vancouver-based production company Whiskaye Films,[8] the company behind the White Ninja web series. The film stars David Alpay and Sara Canning, both of whom previously appeared on The Vampire Diaries television series. Shot in Sault Ste. Marie and Vancouver[9][10], the film premiered on November 30, 2017 at the Whistler Film Festival in Whistler, British Columbia, Canada.[11]
Random information on the term “SON”:
6651
20658
ENSG00000159140
ENSMUSG00000022961
P18583
Q9QX47
NM_138927
NM_019973NM_178880
NP_001278340NP_001278341NP_115571NP_620305
NP_064357NP_849211
SON protein is a protein that in humans is encoded by the SON gene.[5][6]
SON is the name that has been given to a large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression.[7] It is also known as BASS1 (Bax antagonist selected in saccharomyces 1) or NRE-binding protein (Negative regulatory element-binding protein). The most common gene name of this splicing protein- which is only found in Humans (Homo sapiens)- is SON, but C21orf50, DBP5, KIAA1019 and NREBP can also be used as synonyms.[8]
The protein encoded by SON gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing.[6] Mutation in SON gene is associated with ZTTK syndrome.[9]