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Possible Answers: BAL.
Last seen on: The Washington Post Crossword – Oct 5 2018
Random information on the term “BAL”:
A bioartificial liver device (BAL) is an artificial extracorporeal supportive device for an individual who is suffering from acute liver failure.
The first bioartificial liver device was developed by Dr. Kenneth Matsumara and was named an invention of the year by Time magazine in 2001.[1] Liver cells obtained from an animal were used instead of developing a piece of equipment for each function of the liver. The structure and function of the first device resembles that of today’s BALs. Animal liver cells are suspended in a solution and a patient’s blood is processed by a semipermeable membrane that allow toxins and blood proteins to pass but restricts an immunological response.[1]
Advancements in bioengineering techniques in the decade after Matsumara’s work have led to improved membranes and hepatocyte attachment systems.[2] As time has progressed the sources of hepatocytes have increased. Cell sources now include primary porcine hepatocytes, primary human hepatocytes, human hepatoblastoma (C3A), immortalized human cell lines and stem cells.[2]