See 58-Across

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it’s A 13 letters crossword puzzle definition.
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Possible Answers: DUE.

Last seen on: –NY Times Crossword 9 Jan 22, Sunday
USA Today Crossword – Mar 24 2019
LA Times Crossword 6 Feb 19, Wednesday
NY Times Crossword 7 Dec 18, Friday
-NY Times Crossword 16 Nov 2017, Thursday
Premier Sunday – King Feature Syndicate Crossword – Aug 27 2017

Random information on the term “DUE”:

A DNA unwinding element, frequently abbreviated to DUE and on occasion DNAUE, is the initiation site for the opening of the double helix structure of the DNA at the origin of replication for DNA synthesis. It is A-T rich and denatures easily due to its low helical stability, which allows the single-strand region to be recognized by Origin Recognition Complex.

DUE on Wikipedia