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Possible Answers: DUMP.
Last seen on: The Telegraph – Cryptic Crossword – September 15 2017
Random information on the term “DUMP”:
Uridine monophosphate (UMP), also known as 5′-uridylic acid (conjugate base uridylate), is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase uracil; hence, it is a ribonucleoside monophosphate. As a substituent or radical its name takes the form of the prefix uridylyl-. The deoxy form is abbreviated dUMP.
Uridine monophosphate is formed from Orotidine 5′-monophosphate (orotidylic acid) in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase. Uncatalyzed, the decarboxylation reaction is extremely slow (estimated to occur on average one time per 78 million years). Adequately catalyzed, the reaction takes place once per second, an increase of 1017-fold.
In humans, the orotidylate decarboxylase function is carried out by the protein UMP synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder.