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Possible Answers:
SHH.
Last seen on: Universal Crossword – Aug 9 2022 s
Random information on the term “SHH”:
3HO5, 3M1N, 3MXW
6469
20423
ENSG00000164690
ENSMUSG00000002633
Q15465
Q62226
NM_000193NM_001310462
NM_009170
NP_000184NP_001297391
NP_033196
Sonic hedgehog protein (SHH) is encoded for by the SHH gene. The protein is named after the character Sonic the Hedgehog.
This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted.