Summer cooler

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Possible Answers: ICE, ADE, SODA, FAN, POOL, ICEE, ICEDTEA, ICETEA, LIMEADE, SNOCONE, FUELS, ICECREAM, ICEWATER, LEMONADE, ITALIANICE, SEABREEZE, AIRCONDITIONING, GENTLEBREEZE, WINDOWFAN, LIGHTBREEZE.

Last seen on: –Eugene Sheffer – King Feature Syndicate Crossword – Jan 12 2019
Canadiana Crossword – Oct 8 2018
Eugene Sheffer – King Feature Syndicate Crossword – Jun 30 2018
-Eugene Sheffer – King Feature Syndicate Crossword – May 29 2018

Random information on the term “ICE”:

1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA

834

12362

ENSG00000137752

ENSMUSG00000025888

P29466

P29452

NM_033294
NM_033295

NM_009807

NP_150636
NP_150637

NP_033937.2
NP_033937

Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.

ICE on Wikipedia

Random information on the term “ADE”:

Ada Air Sh.p.k was a regional airline based in Tirana, Albania. It operated scheduled services from Albania to Bari, Italy, and overnight freight services for DHL. Its main base was Tirana International Airport Nënë Tereza.

The airline was established in 1991 and started operations on February 3, 1992. It started scheduled flights to Bari on February 5, 1992, and was accepted by the IATA on May 25, 1992. It has operated flights to Greece, Italy, Kosovo and the Republic of Macedonia and charter services throughout the Balkans and Europe. The airline was owned by Julien Roche (50%), vice-president and founder, and Marsel Skendo (50%), president and founder of Ada Air.

Ada Air operated the following international scheduled service (at March 2007):

As of March 2009 the ADA Air fleet included:

Previously operated:

ADE on Wikipedia

Random information on the term “SODA”:

Sodium carbonate (also known as washing soda, soda ash and soda crystals, and in the monohydrate form as crystal carbonate), Na2CO3, is the water-soluble sodium salt of carbonic acid.


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It most commonly occurs as a crystalline decahydrate, which readily effloresces to form a white powder, the monohydrate. Pure sodium carbonate is a white, odorless powder that is hygroscopic (absorbs moisture from the air). It has a strongly alkaline taste, and forms a moderately basic solution in water. Sodium carbonate is well known domestically for its everyday use as a water softener. Historically it was extracted from the ashes of plants growing in sodium-rich soils, such as vegetation from the Middle East, kelp from Scotland and seaweed from Spain. Because the ashes of these sodium-rich plants were noticeably different from ashes of timber (used to create potash), they became known as “soda ash”. It is synthetically produced in large quantities from salt (sodium chloride) and limestone by a method known as the Solvay process.

SODA on Wikipedia

Random information on the term “FAN”:

Abyssal fans, also known as deep-sea fans, underwater deltas, and submarine fans, are underwater geological structures associated with large-scale sediment deposition and formed by turbidity currents. They can be thought of as an underwater version of alluvial fans and can vary dramatically in size, with widths from several kilometres to several thousands of kilometres (see Bengal Fan).

Abyssal (or submarine) fans are formed from turbidity currents.

Turbidity currents start when something, for example an earthquake (or just the inherent instability of newly deposited sediments), triggers sediments to be pushed over the edge of the continental shelf and down the continental slope, creating a submarine landslide. A dense slurry of muds and sands accelerates towards the foot of the slope until the gradient levels off and the turbidity current slows. The slowing current has a reduced ability to transport sediments and deposition of the coarser grains begins, creating a submarine fan. The current continues to slow down as it moves towards the continental rise until it reaches the level bottom of the ocean. This final result is a series of graded sediments of sand, silt and mud and these are known as turbidites, as described by the Bouma sequence.

FAN on Wikipedia

Random information on the term “ICEE”:

The Tbilisiplus30 or the Fourth International Conference on Environmental Education was held at the Centre for Environment Education, Ahmedabad, India between November 24, 2007 and November 28, 2007.

The conference was the fourth in the series of Conferences on environmental education held since the first international conference in Tbilisi (former USSR). The second conference was organised in 1977 in Moscow; and the third conference was held in Thessaloniki in 1997. The United Nations has declared the decade 2005 to 2014 as the “Decade of Education for Sustainable Development” (DESD). This conference underlined the key role of education in achieving sustainable development. The participants and delegates from countries across the globe came together to bridge the gap between environmental education and Education for Sustainable Development. They examined the development of environmental education since the first conference, thirty years ago, and set a global agenda for the DESD. This will be a platform for sharing practices and ideas on initiatives in environmental education throughout the world.

ICEE on Wikipedia