Now we are looking on the crossword clue for: The first feeble change.
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Possible Answers: TWEAK.
Last seen on: Mirror Cryptic Crossword August 13 2017
Random information on the term “TWEAK”:
Darbepoetin alfa (rINN) /dɑːrbəˈpɔɪtᵻn/ is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88,T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compared to epoetin alpha and epoetin beta. It stimulates erythropoiesis (increases red blood cell levels) by the same mechanism as rHuEpo (binding and activating the Epo receptor) and is used to treat anemia, commonly associated with chronic renal failure and cancer chemotherapy. Darbepoetin is marketed by Amgen under the trade name Aranesp.
The drug was approved in September 2001 by the Food and Drug Administration for treatment of anemia in patients with chronic renal failure by intravenous or subcutaneous injection. In June 2001, it had been approved by the European Medicines Agency for this indication as well as the treatment of anemia in cancer patients undergoing chemotherapy.
Dr. Reddy’s Laboratories launched darbepoetin alfa in India under the brand name ‘Cresp’ in August 2010. This is the world’s first follow-on biologic of darbepoetin alfa.