Thing to punch

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Possible Answers: CLOCK.

Last seen on: Universal Crossword – May 9 2018

Random information on the term “CLOCK”:

4H10

406

11865

n/a

ENSMUSG00000055116

O00327

Q9WTL8

NM_001297724

NM_001243048NM_007489NM_001357070

NP_001284653NP_001338733NP_001338734NP_001338735NP_001338736NP_001338737NP_001338738NP_001338739NP_001338740NP_001338741NP_001338742NP_001338743NP_001338744NP_001338745NP_001338746NP_001338747NP_001338748NP_001338749NP_001338750NP_001338751NP_001338752NP_001338753


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NP_001229977NP_031515NP_001343999

Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene, also known as BMAL1, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC.

ARNTL encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian autoregulatory transcription translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

CLOCK on Wikipedia