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Last seen on: The Telegraph – QUICK CROSSWORD NO: 29,056 – May 21 2019
Random information on the term “Timepiece”:
In telecommunication and horology, a slave clock is a clock that depends for its accuracy on another clock, a master clock. Many modern clocks are synchronized, either through the Internet or by radio time signals, to a worldwide time standard called Coordinated Universal Time (UTC) based on a network of master atomic clocks in many countries. For scientific purposes, precision clocks can be synchronized to within a few nanoseconds by dedicated satellite channels. Slave clock synchronization is usually achieved by phase-locking the slave clock signal to a signal received from the master clock. To adjust for the transit time of the signal from the master clock to the slave clock, the phase of the slave clock may be adjusted with respect to the signal from the master clock so that both clocks are in phase. Thus, the time markers of both clocks, at the output of the clocks, occur simultaneously.
Before the computer era, the term referred to electrical clocks that are synchronized periodically by an electrical pulse through dedicated wiring issued by a master clock in the same building. From the late 19th to the mid 20th centuries, electrical master/slave clock systems were widely used in public buildings and business offices, with all the clocks in the building synchronized through electric wires to a central master clock. These older styles of slave clocks either keep time by themselves, and are periodically corrected by the master clock, or require impulses from the master clock to advance. Many slave clocks of these types remain in operation, most commonly in schools.
Random information on the term “CLOCK”:
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the Bmal1 gene, also known as ARNTL, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC.
BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human Arntl gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that Bmal1 is the only clock gene without which the circadian clock fails to function in humans. Bmal1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in Bmal1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.