This time we are looking on the crossword clue for: Vacation place.
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Possible Answers: SPA, CAMP, RESORT, SUMMERCAMP.
Random information on the term “SPA”:
Spa is a Belgian town, located in the Province of Liège, and is the town where the word spa comes from. The town of Spa is situated in a valley in the Ardennes mountains 35 kilometres (22 miles) southeast of Liège and 45 kilometres (28 miles) southwest of Aachen. In 2006, Spa had a population of 10,543 and an area of 39.85 square kilometres (15.39 square miles), giving a population density of 265 inhabitants per km².
Spa is one of Belgium’s main tourist cities. The town of Spa is famous for its several natural mineral springs, and is also the location of mineral water producer Spa, whose mineral water is exported worldwide. Nearby Spa, in the village of Francorchamps, the renowned Circuit de Spa-Francorchamps is situated, which hosts the annual Belgian Grand Prix.
The first beauty pageant in the world was the Concours de Beauté, held in Spa on 19 September 1888. Spa hosted the finish of Stage 2 of the 2010 Tour de France on July 5.
As the famed site of healing cold springs, Spa has been frequented as a watering-place since as early as the 14th century. Though other sources of healing mineral springs have become famous throughout the world, it is the town of Spa which has become eponymous with any place having a natural water source that is believed to possess special health-giving properties, as a spa. The Spa town grew at that time, in the oldest iron and steel center of the country of Liege. The ban Spa, was created around 1335 and included two urban concentrations, “vilhe of Creppe” and “vilhe” Spas, two kilometers away. The steel industry prior to the exploitation of mineral water developed lines of communication, which made possible the development of the spa town.
Random information on the term “CAMP”:
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3′,5′-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. It should not be confused with 5′-AMP-activated protein kinase (AMP-activated protein kinase).
Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 “for his discoveries concerning the mechanisms of the action of hormones”, especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP).
Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs)-protein-coupled receptors. Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline.