This time we are looking on the crossword clue for: Water cooler.
it’s A 12 letters crossword puzzle definition. See the possibilities below.
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Possible Answers: ICE.
Last seen on: –Thomas Joseph – King Feature Syndicate Crossword – Feb 9 2023
–Thomas Joseph – King Feature Syndicate Crossword – Jun 8 2022
–Newsday.com Crossword – Mar 10 2022s
–Thomas Joseph – King Feature Syndicate Crossword – Jan 12 2021
–Thomas Joseph – King Feature Syndicate Crossword – Dec 29 2020
–Thomas Joseph – King Feature Syndicate Crossword – Sep 28 2020
–Thomas Joseph – King Feature Syndicate Crossword – Sep 8 2020
–Thomas Joseph – King Feature Syndicate Crossword – Aug 9 2019
–Thomas Joseph – King Feature Syndicate Crossword – Mar 26 2019
–Thomas Joseph – King Feature Syndicate Crossword – Oct 3 2018
–Thomas Joseph – King Feature Syndicate Crossword – Sep 20 2018
–Newsday.com Crossword – Aug 19 2018
Random information on the term “ICE”:
1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA
834
12362
ENSG00000137752
ENSMUSG00000025888
P29466
P29452
NM_033294
NM_033295
NM_009807
NP_150636
NP_150637
NP_033937.2
NP_033937
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.