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Possible Answers: RANK.
Last seen on: USA Today Crossword – June 16 2018 Saturday Crossword Answers
Random information on the term “RANK”:
3M0D
7185
22029
ENSG00000056558
ENSMUSG00000026875
Q13077
P39428
NM_005658NM_001190945NM_001190947
NM_009421NM_001326601
NP_001177874NP_001177876NP_005649
NP_001313530NP_033447
TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with IAP, and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling. This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases.