Winter quaff

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Possible Answers: NOG, COCOA.

Last seen on: –Thomas Joseph – King Feature Syndicate Crossword – Jan 28 2021
Thomas Joseph – King Feature Syndicate Crossword – Dec 22 2020
Eugene Sheffer – King Feature Syndicate Crossword – Nov 6 2019
Thomas Joseph – King Feature Syndicate Crossword – Mar 19 2019

Random information on the term “NOG”:

1M4U

9241

18121

ENSG00000183691

ENSMUSG00000048616

Q13253

P97466

NM_005450

NM_008711

NP_005441

NP_032737.1
NP_032737

Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. In humans, noggin is encoded by the NOG gene. The amino acid sequence of human noggin is highly homologous to that of rat, mouse, and Xenopus (an aquatic-frog genus).

The protein’s name, which is a slang English-language word for “head,” was coined in reference to its ability to produce embryos with large heads when exposed at high concentrations.

Noggin is a signaling molecule that plays an important role in promoting somite patterning in the developing embryo. It is released from the notochord and regulates bone morphogenic protein (BMP4) during development. The absence of BMP4 will cause the patterning of the neural tube and somites from the neural plate in the developing embryo. It also causes formation of the head and other dorsal structures.

NOG on Wikipedia

Random information on the term “COCOA”:

The cocoa bean, also called cacao bean, cocoa (/ˈkoʊ.koʊ/), and cacao (/kəˈkaʊ/), is the dried and fully fermented seed of Theobroma cacao, from which cocoa solids and, because of the seed’s fat, cocoa butter can be extracted. The “beans” are the basis of chocolate, and of such Mesoamerican foods as mole and tejate.

The word “cocoa” comes from the Spanish word cacao, which is derived from the Nahuatl word cacahuatl. The Nahuatl word, in turn, ultimately derives from the reconstructed Proto Mije-Sokean word *kakaw~*kakawa.

The term cocoa also means

The cacao tree is native to the Americas. It originated in Central America and parts of Mexico. More than 5,000 years ago, it was consumed by pre-Columbian cultures along the Yucatán, including the Mayans, and as far back as Olmeca civilization in spiritual ceremonies. It also grows in the foothills of the Andes in the Amazon and Orinoco basins of South America, in Colombia and Venezuela. Wild cacao still grows there. Its range may have been larger in the past; evidence of its wild range may be obscured by cultivation of the tree in these areas since long before the Spanish arrived. New chemical analysis of residue extracted from pottery excavated at an archaeological site at Puerto Escondido, in Honduras, indicates that cocoa products were first consumed there sometime between 1500 and 1400 BC. Evidence also indicates that, long before the flavor of the cacao seed (or bean) became popular, the sweet pulp of the chocolate fruit, used in making a fermented (5% alcohol) beverage, first drew attention to the plant in the Americas. The cocoa bean was a common currency throughout Mesoamerica before the Spanish conquest.

COCOA on Wikipedia