With 107-Across, give in to despair

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Possible Answers: LOSE.

Last seen on: Premier Sunday – King Feature Syndicate Crossword – Feb 25 2018

Random information on the term “LOSE”:

League of Super Evil (initialized as L.O.S.E. or LOSE) is a Canadian animated television series inspired by the sketch “Once Were Heroes” by Ryan Harper-Brown[citation needed], co-created by Philippe Ivanusic-Vallee, Davila LeBlanc, Peter Ricq, developed by Asaph Fipke, and produced by Nerd Corps Entertainment in conjunction with YTV. The series ran from March 7, 2009 to August 25, 2012. Reruns ceased on YTV on September 2, 2014, when Teletoon picked up where YTV had left off. It also aired in the UK on CBBC.

The League of Super Evil (or “L.O.S.E.”) is a group of Super Villains who are plotting to take over their neighborhood in Metrotown and ultimately the world. Their missions usually involve pranks such as gluing a penny to a chair. While all the other citizens in the neighborhood live in suburban houses, L.O.S.E. has a “secret” evil lair. The League is often at odds with other, more “important” super villains such as Skullossus and also tries to evade getting busted by Metrotown’s heroes.

LOSE on Wikipedia