"With all __ respect . . ."

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Possible Answers: DUE.

Last seen on: Newsday.com Crossword – Oct 17 2017

Random information on the term “DUE”:

A DNA unwinding element, frequently abbreviated to DUE and on occasion DNAUE, is the initiation site for the opening of the double helix structure of the DNA at the origin of replication for DNA synthesis. It is A-T rich and denatures easily due to its low helical stability, which allows the single-strand region to be recognized by Origin Recognition Complex.

DUE on Wikipedia