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Possible Answers: SINE.
Last seen on: The Guardian – Cryptic Crossword No 27,631 – Oct 3 2018
Random information on the term “SINE”:
Short interspersed nuclear elements (SINEs) are non-autonomous, non-coding transposable elements (TEs) that are 50-500 base pairs long. The internal regions of SINEs originate from tRNA and remain highly conserved, suggesting positive pressure to preserve structure and function of SINEs.[1] While SINEs are present in many species of vertebrates and invertebrates, SINEs are often lineage specific, making them useful markers of divergent evolution between species. Copy number variation and mutations in the SINE sequence make it possible to construct phylogenies based on differences in SINEs between species. SINEs are also implicated in certain types of genetic disease in humans and other eukaryotes.
SINEs are classified as non-LTR retrotransposons because they do not contain long terminal repeats (LTRs).[2] There are three types of SINEs common to vertebrates and invertebrates: CORE-SINEs, V-SINEs, and AmnSINEs.[1] SINEs have 50-500 base pair internal regions which contain a tRNA-derived segment with A and B boxes that serve as an internal promoter for RNA polymerase III.[3][1]